• Since the analysis of a complete motor unit is essential

  2018-10-26

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• The present study indicated that induction

  2018-10-26

  

  The present study indicated that induction of glutamatergic markers by nucleotides involved the P2Y4-Gq signaling axis. Expression of the P2Y4 nucleotide receptor was transiently augmented in the course of neuronal differentiation of ESCs, which is coincident with the window of nucleotide-induced v

• Among the epigenetic aberrations of iPSCs DNA methylation is

  2018-10-26

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• br Introduction Human induced pluripotent stem cells hiPSCs

  2018-10-26

  

  Introduction Human induced pluripotent stem voltage gated potassium channel (hiPSCs) carry the whole genetic context of a patient and can be a virtually unlimited source of differentiated cell types of interest. Increasingly, hiPSCs are being applied for disease modeling and drug screening for a

• We speculated that MEKi might decrease

  2018-10-26

  

  We speculated that MEKi might decrease DNA methylation levels through the downregulation of the DNMT3 family. MEKi significantly diminished global DNA methylation levels and, surprisingly, was sufficient to induce high 5hmC levels. Because the TET family of dioxygenases that catalyze the conversion

• Thirdly recent research on the relationship between health

  2018-10-26

  

  Thirdly, recent research on the relationship between health conditions and social networks has highlighted the role that poor health conditions may play in shaping network structure and composition. Poor health conditions may tax the ability of individuals to maintain weak ties leading to more insul

• In order to reduce food insecurity a new

  2018-10-26

  

  In order to reduce food insecurity, a new approach to private emergency food assistance is needed. Traditional food pantries have become run like businesses, as they have expanded over the past three decades (Saul and Curtis, 2013). However, a business model of efficiency, and the typical outcomes o

• br Conclusiones En los procesos de

  2018-10-26

  

  Conclusiones En los procesos de liberalización de los servicios de interés económico general en la Unión Europea, iniciados en la década de los ochenta del siglo pasado, se estableció el servicio universal como una obligación de servicio público que, en cada uno de ellos, habría de garantizar el

• br El ascenso econ mico que ha sostenido China desde

  2018-10-26

  

  El ascenso económico que ha sostenido China desde 1978ha convertido sorafenib tosylate este país en el principal candidato del siglo para reconfigurar el orden económico y político mundial definido décadas atrás por el bloque de países industrializados dentro de los que destacan los Estados Unido

• En el informe anual de Chedraui de afirman estamos

  2018-10-26

  

  En el informe anual de Chedraui de 2010 afirman: “estamos verdaderamente comprometidos con ofrecer todos los días los precios más bajos en cada producto que vendemos. Se requiere un gran esfuerzo para comparar precios y la capacidad de responder rápidamente. Realizamos aproximadamente 1 900 ajustes

• The vicissitudes in the interpretation of Ricardo s

  2018-10-26

  

  The vicissitudes in the interpretation of Ricardo\'s new machinery chapter are well illustrated by the evolution of Paul Samuelson\'s assessment of Wicksell\'s account. Samuelson (1947) was one of the first to mention Wicksell\'s demonstration of the production optimum conditions, made as part of Wi

• br A selective review of literature Mincerian equations

  2018-10-26

  

  A selective review of literature: Mincerian equations, decomposition of income distribution and occupations In the 20th century, Schultz (1961) and Ben-Porath (1967) formulated, despite the lack of theoretical strictness, the relation between education and income. However, the debates and the emp

• br Budget indices The study of the impact of

  2018-10-25

  

  Budget indices The study of the impact of Brazilian budgetary institutions on the fiscal result of the Federal Government is based on three sets of indices constructed based on the methodologies of Alesina et al. (1999) and Dabla-Norris et al. (2010). The methodology used by Alesina et al. (1999)

• br Introduction Law also known

  2018-10-25

  

  Introduction Law 9478/97, also known as “The Oil Law,” regulates the collection and sharing of oil rents between the Brazilian federated entities. A significant portion of these rents is distributed to a subset of states and municipalities that must fulfill some requirements, like proximity to pr

• However to date all clinical trials designed

  2018-10-25

  

  However, to date, all clinical trials designed to low levels of Aβ by either blocking activity of β or γ secretases, preventing Aβ aggregation, or promoting Aβ clearance by immunotherapy have failed (Cummings et al., 2014) emphasizing an urgent need to find new therapies for AD. One of the emerging

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