• br Discussion TLS is an oncologic emergency characterized by

  2018-11-12

  

  Discussion TLS is an oncologic emergency characterized by hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and uremia. It occurs as a result of the rapid destruction of malignant cells, leading to abrupt release of nucleic acids including purine, intracellular ions, and proteins and

• br Introduction Mesenchymal stem cells MSCs have been thorou

  2018-11-12

  

  Introduction Mesenchymal stem PND-1186 (MSCs) have been thoroughly studied during the past two decades. MSCs are multipotent cells that can replicate and have the potential to differentiate into lineages of mesenchymal tissues, including bone, cartilage, and fat. They are also characterized by th

• Introduction Obesity is a metabolic disorder and can be defi

  2018-11-12

  

  Introduction Obesity is a metabolic disorder and can be defined as increased body weight caused by excessive fat accumulation which presents a risk to health with an increase in health problems and/or reduced life expectancy [1,2]. Obesity is characterized by an increased storage of triglycerides i

• br Materials and methods br Acknowledgments

  2018-11-12

  

  Materials and methods Acknowledgments Introduction Human embryonic stem 5ht receptors (hESCs) offer the potential to regenerate any cell in the human body. Initially, many studies utilized serum-containing media to develop differentiation protocols for target cell types (D\'Amour et al., 2

• Although CVB are a frequent cause of

  2018-11-12

  

  Although CVB are a frequent cause of subclinical infection, they may also cause other diseases such as viral myocarditis (Pallansch and Roos, 2001), symptoms of which may be seen either shortly after acute infection potentially triggering severe myocardial dysfunction, or during the chronic phase of

• While the in vivo significance of our in vitro

  2018-11-12

  

  While the in vivo significance of our in vitro findings was examined in xenograft and metastasis studies, we observed a dramatic suppression of tumor growth and metastasis of SW480 CRC Apremilast Supplier by EDA silencing, which is associated with increased apoptosis and reduced expression of a cell

• br Materials and methods br Resource

  2018-11-12

  

  Materials and methods Resource table Resource details This line was derived from a 62-year-old female with familial hypertrophic cardiomyopathy (HCM). HCM is a genetic heart disease with a prevalence of up to 1 in 200 people and is characterised by unexplained hypertrophy of the left ventricl

• Induced pluripotent stem cells have

  2018-11-12

  

  Induced pluripotent stem histamine receptor antagonist have emerged as powerful tool for many applications including disease modelling, drug screening and cell based therapies (Takahashi and Yamanaka, 2016). Therefore, increased efficiency of cell reprogramming is beneficial as it could help reduce

• The following are the supplementary data

  2018-11-12

  

  The following are the supplementary data related to this article. Acknowledgment This work was supported by the Ministry of Science and Technology 973 program of China (2011CB504402, 2012CB966802 and 2012CB966304), and the \"Strategic Priority Research Program\" of the Chinese Academy of Science

• In its effect on enhancing differentiation of a

  2018-11-12

  

  In its effect on enhancing differentiation of a large variety of human pluripotent stem cells, the effect of DMSO was thought to be mediated by causing an exit of the pluripotent cells from the cell cycle and greater effectiveness of differentiation factors in G1 (Chetty et al., 2013). However, in o

• The alternative corneal epithelial stem cell CESC hypothesis

  2018-11-12

  

  The alternative corneal epithelial stem cell (CESC) hypothesis (Majo et al., 2008) accepts that LESCs exist but proposes that these are only used to repair wounds and that, during normal homeostasis, the corneal epithelium is maintained by stem cells, which are present throughout the corneal epithel

• One of these closely related model organisms is

  2018-11-09

  

  One of these closely related model organisms is the old world monkey Macaca (mulatta or fasicularis), which follows a Carnegie staging system that is highly correlated with the timing of human development, particularly in the beginning (Fig. 1). Notably, formation of the primitive streak in macaques

• A recently developed gene editing technology using RNA guide

  2018-11-09

  

  A recently developed gene-editing technology using RNA-guided endonuclease (Gaj et al., 2013), which allows the desired gene to be inserted into a genomic safe harbor (GSH) area (Papapetrou et al., 2011), should be considered to avoid undesirable random genomic insertion of EOS-C(3+)-KR in the gener

• One major drawback of current melanoma

  2018-11-09

  

  One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev

• MBD was originally identified as a

  2018-11-09

  

  MBD3 was originally identified as a member of the methyl-CpG binding domain (MBD) family of proteins (Hendrich and Bird, 1998). However, unlike MBD members MECP2 and MBD1, 2, and 4, MBD3 does not bind methylated DNA (Hendrich and Bird, 1998; Zhang et al., 1999). Three MBD3 isoforms (MBD3A, B, and C)

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