• The reprogramming of somatic cells was originally demonstrat

  2018-10-24

  

  The reprogramming of somatic GPCR Compound Library was originally demonstrated by producing cloned frogs using somatic cell nuclear transfer (SCNT) into Xenopus oocytes (Gurdon et al., 1958). Reprogramming of mammalian somatic cells has also been achieved using SCNT into oocytes, including those of

• br Results br Discussion We report on

  2018-10-24

  

  Results Discussion We report on the derivation and full characterization of two hESC lines (SZ-ALS1 and SZ-ALS3) with a GGGGCC expansion of approximately 270 repeats. Our C9 hESC lines were established from embryos obtained through PGD from a woman with a C9 mutation with >40 repeats in her pe

• We assessed levels of cell death

  2018-10-24

  

  We assessed levels of cell death using annexin V and propidium iodide staining. The tp53 animals showed a 20% increase in erythroid cell death when assessed by propidium iodide staining (p = 0.02, Figures 4A and S3A), but no increase in annexin V staining (Figures S3A and S3B), similar to what was o

• To study the cellular and molecular events

  2018-10-24

  

  To study the cellular and molecular events of FTD3, we derived a disease model using human iPSCs from patients carrying the 31449G > C mutation in CHMP2B and isogenic controls generated via the CRISPR/Cas9 system with subsequent in vitro neuronal differentiation. Our model not only confirmed partly

• br Results Disease modeling using iPSCs can be

  2018-10-24

  

  Results Disease modeling using iPSCs can be confounded by phenotypic variation resulting from genetic differences between individual iPSC lines (Merkle and Eggan, 2013). To overcome this obstacle, we sought to generate isogenic cell lines by targeted correction of the point mutation in the SOD1 i

• A total of endogenous genes

  2018-10-24

  

  A total of 508 endogenous genes were differentially expressed in LU07+Dox brain metabolism when compared with LU07, H9, and H9+Dox cells including several pluripotency- and/or cancer-related genes (Figure 5D). However, the fact that the Pluripotency Scores of LU07+Dox cells and LU07 cells were indi

• br Introduction Proper function of

  2018-10-24

  

  Introduction Proper function of the cerebral cortex requires the coordinated activity of two distinct neuronal populations: excitatory projection neurons and inhibitory GABAergic interneurons (cINs). In both mice and humans, roughly half of all cINs originate within the medial ganglionic eminence

• In an in vivo study the transplantation of hPSC SCP

  2018-10-24

  

  In an in vivo study, the transplantation of hPSC-SCP-SCs into a sciatic nerve-injured mouse promoted nerve fiber regeneration, and the transplanted cells integrated into renewed influenza m2 protein (Figures 5 and S6). However, without SC transplantation, demyelinated axons and nerve defects were no

• Fig b shows that the population of the upper

  2018-10-24

  

  Fig. 1b shows that the population of the upper sublevel of the 4I11/2 multiplet with the 5-Azacytidine of 2110 cm−1 does not depend on the rate of relaxation transitions relaxation to the main 4I9/2 level. The calculations proved that in order to adequately model the changes of the emission spectr

• br Assuming the curvature of the beam shape to be

  2018-10-24

  

  Assuming the curvature of the beam shape to be constant along the length of the piezoelectric actuator, we can take that where the coefficient =e31(–) is the same for all actuators, is the electrical voltage applied to the ith piezoelectric actuator. Thus, we assume that each actuator is fixed

• br Methods br Results br Discussion This

  2018-10-24

  

  Methods Results Discussion This study investigated which drug categories were responsible for the growth in fatal overdoses between 1999 and 2014 or sub-periods. Three challenges were encountered when attempting to answer this seemingly simple question. First, current death certificate data

• These results confirm that group position theory a

  2018-10-24

  

  These results confirm that group position theory, a sociological social psychological theory that explains negative emotions arising from intergroup relations, can be applied to the study of affect-related health behaviors and outcomes. In his original articulation of group position theory, Blumer a

• br Materials and methods br Results and discussion br Conclu

  2018-10-24

  

  Materials and methods Results and discussion Conclusions The centre composite design of response surface methodology was successfully used in optimising the reaction conditions for biodiesel production from waste vegetable oil in the presence of Biotin-tyramide heterogeneous catalyst prepar

• has been a remarkable year of scientific achievements from a

  2018-10-23

  

  2014 has been a remarkable year of scientific achievements, from advances in our understanding of molecular pathways of human diseases to the development of new interventional tools to tackle them. Here, we highlight some promising initiatives and success stories from the past year with clear transl

• The original premise of this

  2018-10-23

  

  The original premise of this study was that the melanoma-enriched miRNAs identified in our previous study (Stark et al., 2015) would be translated directly to the expression observed in melanoma patient-derived serum. Evidence for this notion is apparent in the serially collected stage IV melanoma p

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