• CXCL has been previously identified as an estrogen regulated

  2018-10-20

  

  CXCL12 has been previously identified as an estrogen-regulated gene in estrogen receptor (ER)-positive ovarian and breast cancer hydroxypropyl beta cyclodextrin (Jaerve et al., 2012). Here we show that in the endometrium, E2 significantly increased CXCL12 expression, suggesting a mechanism by which

• br Conclusion br Contributions br Competing interests br Fun

  2018-10-20

  

  Conclusion Contributions Competing interests Funding This study was financially supported by German Academic Exchange Service/Federal Ministry of Education and Research (grant # D/09/04774), Center for Regenerative Therapies Dresden (Seed Grant # 09-08), Simon Fougner Hartmanns Family Fo

• Using ESNPs to repair damaged tissue in neurodegenerative di

  2018-10-20

  

  Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these buy XL184 are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well as our own transplan

• HSCs isolated by the set of markers which are

  2018-10-20

  

  HSCs isolated by the set of markers which are Lin−/Sca-1+/C-kit+ (LSK) have been also reported to be heterogeneous (Osawa et al., 1996). Moreover, Sca-1 expression differs between mouse strains and therefore is not very effective to enrich HSCs (Spangrude and Brooks, 1993). Likewise, the SLAM family

• The host immune response has

  2018-10-20

  

  The host immune response has been identified as a critical regulator of tumor development and progression (Dunn et al., 2004; Fridman et al., 2013; Hadrup et al., 2013). Several types of immune myeloperoxidase participate in immunosurveillance by direct killing or production of cytokines. Our expres

• Next to the significant evidence that CpG methylation of the

  2018-10-20

  

  Next to the significant evidence that CpG methylation of the HLA-G promoter is important for the transcriptional activity of the gene (Moreau et al., 2003; Mouillot et al., 2005), HLA-G leukotriene receptor antagonist is also post-transcriptionally regulated by the 3′UTR. Several polymorphic sites

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Intestinal crypts contain stem cells and their transit-amplifying (TA) daughter cells. Cells exiting the proliferative crypts onto the villi terminally differentiate into enterocytes, goblet cells, and enteroendocr

• br Experimental Procedures br Acknowledgments

  2018-10-20

  

  Experimental Procedures Acknowledgments Introduction The kidney contains multiple specialized cell types that have district physiological functions. During embryogenesis, the urogenital system, including the kidney, is derived from the intermediate mesoderm of the developing embryo (Herzlin

• The most significant finding in these studies was the fold

  2018-10-20

  

  The most significant finding in these studies was the 10-fold enhanced expansion of transplantable HSCs in mice engrafted with IK6-transduced human CD34+ CB cells. This was indicated both by the higher numbers of CD34+CD38− dihydrofolate reductase inhibitor antibacterial regenerated from the IK6-tr

• Main Text br Acknowledgments The

  2018-10-20

  

  Main Text Acknowledgments The authors would like to thank all delegates for their input into the workshops that led to the contents of this white paper (Table S2). Introduction The type II clustered regularly interspaced short palindromic repeat (CRISPR) systems and the associated Cas9 nucle

• To analyze whether the pB Tet GOI system

  2018-10-20

  

  To analyze whether the pB-Tet-GOI system expresses proteins that are biologically active and at sufficient levels to direct specific neuronal differentiation, HuNPCs were nucleofected with each response plasmid and differentiated for up to 6 weeks. Live gaba receptors were imaged daily for GFP and T

• Of importance was our finding of changes in other PD

  2018-10-20

  

  Of importance was our finding of changes in other PD-associated genes, including SNCA (Krüger et al., 1998; Polymeropoulos et al., 1997; Singleton et al., 2003; Zarranz et al., 2004). SNCA is a presynaptic protein and function in regulating synaptic vesicle and neurotransmitter release. Aggregates o

• Since the discovery of these cells Ingram

  2018-10-20

  

  Since the discovery of these cholecystokinin receptor (Ingram et al., 2004), secondary colonies have been generated in several studies to assess the immaturity of ECFCs from blood or vascular wall and hierarchize them (Alphonse et al., 2015; Ingram et al., 2005; Patel et al., 2016). The aim of this

• br Introduction The adult prostate gland contains

  2018-10-20

  

  Introduction The adult prostate gland contains a simple columnar epithelium composed of luminal secretory and underlying basal fccp with a scarce neuroendocrine cell component. These epithelial cells are derived from a rare, relatively quiescent stem cell population that maintains glandular home

• Collectively we have evaluated the impact of

  2018-10-20

  

  Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

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