• N1-Methylpseudouridine br Experimental section br Acknowledg

  2024-12-04

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• T 705 In the current investigation we studied the effect of

  2024-12-04

  

  In the current investigation, we studied the effect of propofol on prostate cancer cells. Propofol is one of the most commonly used drugs in the critical care setting and for the induction of general anesthesia and moderate and deep sedation intraoperatively. Recent studies indicated that propofol e

• Synaptic scaling up is induced within

  2024-12-03

  

  Synaptic scaling up is induced within primary visual crizotinib synthesis (V1) by brief sensory deprivation (Desai et al., 2002; Lambo and Turrigiano, 2013). Several studies have examined the transcriptional changes within extracts of V1 following visual deprivation protocols (Lachance and Chaudhur

• Dihydrotestosterone br The lipoxygenase pathway in

  2024-12-03

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) Dihydrotestosterone [86], [87], [88]. Different LOXs oxidize fatty acid

• br Acknowledgements br Introduction Diabetic complications a

  2024-12-03

  

  Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of zingerone through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose reductase

• Obesity is defined as a body mass index BMI of

  2024-12-02

  

  Obesity is defined as a body mass index (BMI) of 30kg/m2 or higher and is known to have a very close association with the risk of developing cancers (Hsueh and Deng, 2016). Several theories exist as to how this link is defined with respect to various cancers, one of which involves the effect of obes

• Adiponectin belongs to the CTRP C q

  2024-12-02

  

  Adiponectin belongs to the CTRP (C1q/TNF-related protein) superfamily. Except for adiponectin, 15 additional members have been identified (CTRP1-15) (Schaffler and Buechler, 2012). Of all the CTRPs, CTRP9 has the highest identity to adiponectin in globular domain (Wong et al., 2009). The structure o

• NLX a k a F or befiradol exhibits

  2024-12-02

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in 98 receptor to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionally, it ha

• br Introduction Cell motility is fundamentally important in

  2024-12-02

  

  Introduction Cell motility is fundamentally important in morphogenesis, wound healing, and the immune response. One of the best-studied basic types of cell movement is lamellipodial motility [1, 2], characterized by a thin (∼0.1–0.2 μm), broad (∼10–40 μm) motile appendage containing a dynamic 129

• There has been growing interest over computational methods

  2024-12-02

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it atp citrate lyase inhibitor has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity re

• Because LTs are proved to mediate multiple biological and pa

  2024-12-02

  

  Because LTs are proved to mediate multiple biological and pathological responses in various disease states, the 5-LO biosynthetic pathway producing LTs from AA have been the target of drug discovery efforts for over two decades. As observed from literature, a pile of research efforts has been direct

• fructose 1 6 bisphosphatase NOXA a BH only protein

  2024-12-02

  

  NOXA, a BH3-only protein, is best known as a selective inhibitor of MCL-1, which is a highly expressed pro-survival protein in many human malignancies [30]. In addition, NOXA was recently proven to act as a direct activator via directly binding to BAX to induce apoptosis [31]. Given that its levels

• 5-Iodotubercidin br Materials and methods br Results br Disc

  2024-12-02

  

  Materials and methods Results Discussion CUs, which have been used as traditional medicine for thousands of years in East Asian countries, have the potential to be used for cancer chemoprevention and chemotherapy [17], [18], [19], [20]. CuB is one of the most promising agents as it is repor

• Several genes related to metabolism post

  2024-12-02

  

  Several genes related to metabolism, post-transcriptional regulation, chromatin structure, and signaling pathways are required for the sexual development and virulence of G. zeae (Baldwin et al., 2010, Bluhm et al., 2007, Ding et al., 2009, Han et al., 2007, Hou et al., 2002, Jenczmionka et al., 200

• When skeletal muscle ages there is

  2024-12-02

  

  When skeletal muscle ages, there is an increase in frailty, which is coincident with a decrease in muscle mass and function—this condition is called sarcopenia (Cruz-Jentoft et al., 2010). It has been shown that one of the major pathways downregulated at the onset of sarcopenia is the mitochondrial

15701 records 41/1047 page Previous Next First page 上5页 4142434445 下5页 Last page