• E-64-c br Voltage dependent anion channel VDAC is a ubiquito

  2021-10-13

  

  Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially

• br Acknowledgements br Introduction Muscle FBPase

  2021-10-12

  

  Acknowledgements Introduction Muscle FBPase is very sensitive to AMP inhibition and in the presence of physiological concentrations of this effector in muscle fibres FBPase should be almost completely inactive [1], [2]. Recently, we have presented evidence that, in vitro, muscle aldolase binds

• It has been reported that the FDP synthase

  2021-10-12

  

  It has been reported that the FDP synthase in Hevea latex has a major role to produce the starter substrate FPP for the prenyl chain elongation in natural rubber biosynthesis (Takaya et al., 2003). Accumulation of HbFDP mRNA transcripts in different tissue types including latex (natural rubber) prod

• Colorectal cancer CRC is the

  2021-10-12

  

  Colorectal cancer (CRC) is the leading cause of cancer deaths in Taiwan and is also a most common cancer in the world (Huang et al., 2012, Jemal et al., 2011). With early detection and treatment in the initial stage, CRC can be recognized as curable in comparison with other malignant tumors (Levin e

• br FAAH regulation of ECB signaling ECBs

  2021-10-12

  

  FAAH regulation of ECB signaling ECBs are fatty orexin a receptor amides and monoacylglyerols functioning as neuromodulator lipids that exhibit rapid (within seconds) on-demand biosynthesis in response to neuronal activation, and are subsequently degraded by specialized catabolic enzymes. There

• The replenishment time course of already tethered

  2021-10-12

  

  The replenishment time course of already-tethered vesicle to became release ready, was examined by TIRFM imaging combined with calcium uncaging. By UV-flash photolysis of caged calcium, intracellular calcium concentration raises rapidly and homogenously throughout the cell (Ellis-Davies, 2008). Upon

• The present experimental study identified

  2021-10-12

  

  The present experimental study identified remarkable protective effects for celecoxib against renal toxicity caused by CSA. All aspects of CSA nephrotoxicity, functional, inflammatory, fibrotic, and structural, were improved by celecoxib. Mechanistically, pharmacological and immunostaining protein e

• The strict control of Spi

  2021-10-12

  

  The strict control of Spi1 expression is critical for proper myeloid cell fate determination, and genetic or epigenetic changes in the Spi1 gene frequently contribute to the leukemogenesis in mice and human. It is has been shown that Spi1 expression is frequently downregulated in human AML patients

• Dithiodipyridine also known as aldrithiol is a known zinc

  2021-10-12

  

  2,2′-Dithiodipyridine , also known as aldrithiol, is a known zinc ejector, targeting for instance the zinc finger in nucleocapsid protein of human immunodeficiency BD 1047 dihydrobromide receptor type 1. inhibited G9a activity with IC = 0.65 µM and GLP with IC = 2.6 µM. We also tested disulfide cys

• It was reported that GPR is expressed on macrophages in

  2021-10-12

  

  It was reported that GPR120 is expressed on macrophages in adipose tissue (Oh et al., 2010). Whether GPR120-positive Donitriptan hydrochloride australia in human and rat pancreas belongs to macrophages was studied. CD68 is a transmembrane glycoprotein that is highly expressed by human monocytes and

• Then the seven complexes GLOI indomethacin GLOI zomepirac GL

  2021-10-12

  

  Then the seven complexes (GLOI-indomethacin, GLOI-zomepirac, GLOI-fenoprofen, and GLOI-ketoprofen, GLOI-tolmetin GLOI-curcumin, and GLOI-bisdemethoxycurcumin) were energy-minimized to remove unfavorable steric strain relative to the force field adopted. Further MD simulations were carried out based

• 3-Deazaneplanocin A Several studies have found decreased

  2021-10-12

  

  Several studies have found decreased astroglial and neuronal cell numbers and 3-Deazaneplanocin A damage after OP exposure. Neuronal loss and brain lesions increase proportionally to the severity and duration of OP-induced seizures (Albuquerque et al., 2006, Carpentier et al., 2000, Gullapalli et al

• pitavastatin So far the functional significance of GluR A an

  2021-10-12

  

  So far, the functional significance of GluR-A and GluR-B in synaptic plasticity has been best studied in the context of long-term potentiation of synaptic transmission in vitro in the hippocampus and the regulation of synaptic strength in paradigms underlying activity-dependent learning in vivo Taka

• LbGlcK crystallized as a ligandless dimer in

  2021-10-11

  

  LbGlcK crystallized as a ligandless dimer in the asymmetric unit of space group P21 (Fig. 1a) with two identical subunits stabilized by a large contact surface area of 2295 Å2 (13% of the total surface area) as determined by the Protein Interfaces, Surfaces, and Assemblies (PISA) server [18]. Each m

• To date types of glucose transport protein have been discove

  2021-10-11

  

  To date, 14 types of glucose transport protein have been discovered, each having its own specific functions with different distributions [33]. Among these, GLUT4 is particularly important for maintaining glucose metabolism homeostasis and insulin sensitivity, since it is involved in glucose transpor

15718 records 548/1048 page Previous Next First page 上5页 546547548549550 下5页 Last page