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The quaternary structure of many of the family B members
2020-05-28
The quaternary structure of many of the family B members (i.e., secretin, glucagon, glucagon-like peptide and Coumarin receptors) have been actively studied and it has been demonstrated that they can form homodimers/oligomers (Gao et al., 2009; Ng & Chow, 2015; Ng, Lee, & Chow, 2013). Harikumar, Pi
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It is well known that nanostructured transition
2020-05-28
It is well known that, nanostructured transition metal oxides are the most promising candidates as electrode for pseudocapacitors due to their attractive properties such as environmentally friendly, high theoretical capacitance, low cost and easily abundant [15], [16]. Numerous investigations have b
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Homologous recombination HR has important roles in
2020-05-28
Homologous recombination (HR) has important roles in the repair of stalled or collapsed DNA replication forks, as well as of DNA double-strand breaks. Among the factors required for HR in human Cy7 NHS ester (non-sulfonated) are RAD51, BRCA1, and BRCA2 (Davies et al., 2001, Sung and Klein, 2006, Xi
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L-Mimosine sale In rats exposed to day of nicotine withdrawa
2020-05-27
In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w
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Recently cross talk between DDR and the insulin receptor and
2020-05-26
Recently, cross-talk between DDR2 and the insulin receptor and between Notch1 and DDR1 was proposed. Stimulation of cells with collagen I and insulin promotes Tyr740 as well as total tyrosine phosphorylation of DDR2 receptor to a greater extent than the phosphorylation stimulated by collagen I alone
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br Experimental Procedures br Acknowledgments br Introductio
2020-05-26
Experimental Procedures Acknowledgments Introduction The ability of the affiliative and nurture hormone oxytocin (OT) to attenuate stress has been observed across psychological, neurological, and physiological levels [1], [2]. We and others have demonstrated that, in the gut, OT can lessen
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droperidol receptor br Acknowledgements This work was
2020-05-26
Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241). Introduction Fluoride, as a member of the halogen group of elements, naturally existed in water, soil, animals, and plants around the world (Singh et al., 2018), and it is present in trace
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Although shoulder dub off on
2020-05-26
Although shoulder dub-off on gun drills has significant influence on chip transportation behavior, most commercial gun drills adhere to a fixed design of 20° that has limited scientific basis. To determine the effects of shoulder dub-off on chip evacuation, 5 different angles ranging from 0° to 30°
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Neurons in the striatum unlike those
2020-05-26
Neurons in the striatum, unlike those in the Oseltamivir phosphate and cerebellum, do not form a layered or columnar structure. Although they appear to be randomly distributed, they are actually scattered in two embryologically different compartments called striosomes (often referred to as “patches”
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Industrial fermentation aims to produce valuable products fr
2020-05-26
Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r
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Although it is believed that CYP induction
2020-05-26
Although it is believed that CYP induction is regulated in humans in principle in the same fashion as in animals, some species differences in CYP3A enzymes induction were observed. Rifampicin is known to be a potent inducer of CYP3A4 in human hepatocytes, whereas pregnenolone-16α-carbonitrile (PCN)
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SAR131675 mg Epigenetic silencing of genes that determine tu
2020-05-26
Epigenetic silencing of genes that determine tumor invasiveness, growth patterns of tumors, and tumor-cell apoptosis12, 29 may also affect the expression of drug-metabolizing enzymes, thereby providing an additional genetic mechanism in pharmacogenomics. Trisomy 8 that contains wild-type GGH could b
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Sweroside receptor Three new trans P Hs AlP
2020-05-26
Three new trans-P4Hs (AlP4H, MiP4H and ScP4H) discovered by a genome mining approach in this study were all located in branch A containing DaP4H sequence. Although another three candidates from Amycolatopsis mediterranei, Bradyrhizobium sp. ORS285 and O. indicum were successfully expressed as solubl
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br Conflict of interest statement br Introduction Endothelin
2020-05-26
Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle
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The Kaempferia parviflora extract met the criteria for a
2020-05-26
The Kaempferia parviflora extract met the criteria for a non-competitive interaction with CYP1A1 based on the decrease of Vmax and unchanged Km. The high Ki value and low IC50, as well as the high Km value was indicative of the weakness of the interaction between the Kaempferia parviflora extract an
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