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The underlying mechanisms of how progesterone prolongs pregn
2019-07-17
The underlying mechanisms of how progesterone prolongs pregnancy, although not completely understood, are thought to have to do with reduction in uterine contractility, antimicrobial protein up-regulation, immunosuppression, and inflammatory inhibition. Specific to preterm PROM, progesterone has bee
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br Materials and methods br Results br
2019-07-17
Materials and methods Results Discussion The EP4 Estradiol 17-(β-D-Glucuronide) sodium salt for PGE2 is similar to the EP1, EP2 and EP3 receptors in that they all have seven transmembrane segments and are coupled to Gα subunits of heterotrimeric G proteins, with a different Gα subunit for
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Moreover Hypericum perforatum L was also
2019-07-17
Moreover, Hypericum perforatum L. was also included in the initial screening, showing only a weak percentage of inhibition on both enzymes. In fact, it was not selected among the most active plants. The phytochemical profiles of these three Hypericum species were already reported to be significantly
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br Conclusions br Acknowledgements This work was
2019-07-17
Conclusions Acknowledgements This work was supported by the Science and Technology Planning Projects of Guangdong Province (2014A020210027); the Major Scientific Research Projects of Universities in Guangdong Province (2016KZDXM042); the Natural Science Foundation of Guangdong Province (2015A0
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br The classical ubiquitination pathway Ubiquitination is an
2019-07-17
The classical ubiquitination pathway Ubiquitination is an enzymatic process that involves the addition of an ubiquitin protein to a substrate that usually becomes inactivated followed by degradation in the proteasome; however, several other functions have also been described. For the discovery of
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Imidazo purine diones were another cluster of compounds iden
2019-07-17
1-Imidazo[2,1-]purine-2,4(3,8)-diones were another cluster of compounds identified from the Chembridge screen (). A benzyl group at the R2 position was preferred over a phenyl or 2-phenylpropyl (. and ), and -substitution of the benzyl group increased potency to the nanomolar level ( IC=0.20μM . ).
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br Materials and methods br
2019-07-17
Materials and methods Results Discussion GOS potently inhibited SRD5A1 in COS-1 cells (Fig. 4A) and rat Leydig cells (Fig. 4B), possibly attenuating testosterone activation into DHT. It has been reported that gossypol inhibited human SRD5A1 with IC50 of 7 × 10−6 M [28]. Interestingly, gossy
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In summary our data demonstrated a biological function
2019-07-17
In summary, our data demonstrated a biological function of cpt1a gene from large yellow croaker. In particular, we indicated the effects of fasting on free carnitine status, CPT1 kinetics, and cpt1a mRNA expression in liver of large yellow croaker. During short-term fasting, the fish liver may have
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br Methods for assessing TLS While the precise quantificatio
2019-07-16
Methods for assessing TLS While the precise quantification of restricted DNA synthesis events is possible (e.g. unscheduled DNA synthesis (UDS) reveals NER), so far, it is impossible to identify TLS stretches of only a few nucleotides within the background of bulk DNA replication of normal DNA. N
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In general the DNMT encompass three different structural reg
2019-07-16
In general, the DNMT encompass three different structural regions: N-terminal regulatory domain, C-terminal catalytic domain and a central linker region (). The N-terminal regulatory domain is particularly implicated in determining subcellular localization of the DNMT and in allocating unmethylated
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br Materials and methods br
2019-07-16
Materials and methods Results Discussion Recently, circRNAs have been found to play important diagnostic or prognostic roles in different tumors. For example, aberrant expression levels of different circRNAs are found in ovarian cancer, lung cancer, renal cancer, gastric cancer and particip
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In contrast to PEGylated proteins which tend
2019-07-16
In contrast to PEGylated proteins which tend to have reduced acetylcholine receptors in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in th
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In the present study we have
2019-07-16
In the present study, we have examined, an alternative approach for introduction of Hyp into bacterial, non-animal collagens. Previously, Gruskin and colleagues [27] had shown that Hyp could be introduced into recombinant mammalian collagen sequences in E. coli through a mechanism of co-translationa
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br Patients and methods br Results Table shows
2019-07-16
Patients and methods Results Table 1 shows relevant demographic and clinical characteristics of the 123 patients in the cohort. BAL fluid samples were obtained at a median of 172.5 days after allo-HSCT (range 3 days to five years). Discussion The definitive abandonment of traditional cultu
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Introduction Cyclin dependent kinases CDKs are a
2019-07-16
Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as Droxinostat chemical and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins
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