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Recent reports have indicated the functional significance
2018-11-08
Recent reports have indicated the functional significance of FOXM1 in pluripotent cells. FOXM1 is required for the maintenance of pluripotency in mouse embryonal carcinoma (EC) cells, via direct regulation of Oct4 transcription (Xie et al., 2010). More importantly, FOXM1 is important for maintaining
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Introduction Multipotent stromal cells also referred
2018-11-08
Introduction Multipotent stromal cells, also referred to as mesenchymal stem histone demethylase (MSCs), are an heterogeneous subset of stromal cells present in several tissues including bone marrow, bone, adipose tissue, skin, kidney, umbilical cord and placenta (Friedenstein et al., 1968). The m
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br Introduction Human leukocyte antigen G HLA G
2018-11-08
Introduction Human leukocyte antigen G (HLA-G) belongs to the non-classical HLA class I angiotensin ii and is a tolerogenic molecule that acts on cells of both innate and adaptive immunity. Besides its immunosuppressive function in transplantation, autoimmunity and tumour progression, HLA-G expr
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We used immunohistochemistry to measure
2018-11-08
We used immunohistochemistry to measure the expression of RUNX2, SP7, and GFP in the induced 2.3 kb Col1a1-GFP mESCs. RUNX2, SP7, and the 2.3 kb Col1a1-GFP were highly expressed in the induced order ldv on day 19. RUNX2 and SP7 were colocalized in nuclei, and 2.3 kb Col1a1-GFP was largely observed
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Retinoids vitamin A are important
2018-11-08
Retinoids (vitamin A) are important for a number of physiological and developmental processes including reproduction. Retinoic acid, one of the retinoids, plays an essential role in early development and maintenance of specific tissue types. Khillan and colleagues demonstrated that retinol can be us
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The NAD dependent protein silent information regulator Sir i
2018-11-08
The NAD-dependent protein silent information regulator 2 (Sir2) is a deacetylase for histones and other proteins and a key regulator of life span in several organisms. Sirtuin (SIRT)1 of the Sirtuin family is the closest homolog of yeast Sir2 in mammals and has critical functions in the regulation o
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br Results br Discussion These
2018-11-08
Results Discussion These data identify a transmembrane molecule that negatively regulates AKT signaling via modulation of mTORC2 (Figure 4E). It joins the small number of mTORC2 upstream interactors, such as ribosome components (Zinzalla et al., 2011). Its transmembrane, putative cell-surface
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Previously in vitro studies of CIPN were performed in
2018-11-08
Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al., 2
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Human leukocyte class I HLA I molecules are critical for
2018-11-08
Human leukocyte class I (HLA-I) molecules are critical for antigen presentation to CD8+ cytotoxic T-lymphocyte (Garrido et al., 1993), and are understood to be widely expressed on the cell surface of all normal human tissues (Daar et al., 1984). However, HLA-I expression has been reported to be abse
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We and others have shown
2018-11-08
We and others have shown previously that the evolutionarily conserved Notch signaling pathway plays an important role in early embryonic pituitary development (Kita et al., 2007; Raetzman et al., 2004, 2007; Zhu et al., 2006). Delta/Notch signaling, mediated by the critical transcription factor RBP-
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Surprisingly few studies on human fetal livers have reported
2018-11-07
Surprisingly, few studies on human fetal livers have reported that the hematopoietic progenitor markers CD34, CD117, CD90, CD133, and CD44 are also expressed on a subset of human hepatoblasts and/or precursors of hepatoblasts depending on the embryonic stage examined (Table S1). Most of the EpCAM+ h
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Some countries with socialized medicine concerned with
2018-11-07
Some countries with socialized medicine concerned with optimizing resources and implementing practical methods to diagnose prevalent diseases have conducted telemedicine experiences for the diagnosis of OSA. Recently, Coma del Corral et al. have published the results of the pilot study they carried
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Vaccine hesitancy among healthcare providers must
2018-11-07
Vaccine hesitancy among healthcare providers must be addressed as studies in high, middle and limited resource settings consistently have shown that the majority of parents look to their child\'s healthcare provider for information and advice on vaccine-preventable diseases, vaccines and the recomme
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It therefore appears that an autoimmune
2018-11-07
It therefore appears that an autoimmune reaction in CIDP may result from a TLR4-driven activation of innate immunity by MSRV-Env protein in immune and neuroglial cell types with potential downstream superantigen-like effects when T-cells are recruited and exposed to MSRV-Env (Perron et al., 2001). A
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In total the selected model explained se and
2018-11-07
In total, the selected model explained 60% (se=8%) and 98% (se=9%) of the phenotypic variation in MDD and SDD, respectively (Fig. 3). Strikingly, the effect of the shared couple environment contributed as much as 14% (se=7%) and 22% (se=7%) of the phenotypic variance in MDD and SDD respectively. For
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