• However to date all clinical trials designed

  2018-10-25

  

  However, to date, all clinical trials designed to low levels of Aβ by either blocking activity of β or γ secretases, preventing Aβ aggregation, or promoting Aβ clearance by immunotherapy have failed (Cummings et al., 2014) emphasizing an urgent need to find new therapies for AD. One of the emerging

• br Acknowledgements We are indebted to K Basler S

  2018-10-25

  

  Acknowledgements We are indebted to K. Basler, S. Bray, M. Freeman E. Martín-Blanco and F. Schweisguth for fly lines. Some antisera used in this work were obtained from the Developmental Studies Hybridoma Bank (DSHB) developed under the auspices of the NICHD and maintained by the University of Io

• br Experimental design materials and methods The vineyard is

  2018-10-25

  

  Experimental design, materials and methods The vineyard is located approximately 15.5km east to the nearest Bureau of Meteorology (BOM) weather station (Ararat Prison Station, Vic, Australian BOM Station No. 089085). The long-term mean January temperature (MJT) and annual average rainfall recorde

• glibenclamide The study had a number of

  2018-10-25

  

  The study had a number of limitations. First, individuals in the ADHD group had lower IQ than controls; however, analyses were run with and without IQ as a covariate and this did not change the results. Second, the use of sLORETA may constrain the interpretation as the images this package produces l

• br Conflict of interest br Acknowledgements This

  2018-10-25

  

  Conflict of interest Acknowledgements This work was supported by the Economic and Social Research Council (grant number ES/L003155/1). Introduction The attainment of flexible and effective emotion regulation skills during childhood is considered a key developmental task in support of psych

• br Conflict of interest br Acknowledgements This work was su

  2018-10-25

  

  Conflict of interest Acknowledgements This work was supported by a grant from the Belgian National Fund for Scientific Research (FNRS 3.4.516.08.F). Stéphane A. De Brito was supported by a research fellowship from the Swiss National Science Foundation (SNSF PA00P1_139586). Introduction Att

• Our goal here was to develop a mouse model

  2018-10-25

  

  Our goal here was to develop a mouse model of effects of early life adversity on executive function with a focus on the subdomain of cognitive flexibility (also called updating in the RDoc system). Additionally, we sought to investigate how early life stress might contribute to the development of ad

• Although not surviving correction for multiple comparisons h

  2018-10-25

  

  Although not surviving correction for multiple comparisons, high levels of both guilt and shame-proneness were associated with attenuated dmPFC cortical thinning with age. The involvement of the dmPFC in shame is consistent with hypotheses and with previous fMRI study findings (Roth et al., 2014). T

• The current study focused on potential links between reward

  2018-10-25

  

  The current study focused on potential links between reward-based learning and decision-making early in development and exposure to adverse life events. In humans, adversity has been linked to a variety of alterations in reward processing, including both potentiated and attenuated motivation to appr

• br TCR transgenic hosts The

  2018-10-25

  

  TCR transgenic hosts The AAD + transgenic mouse expresses an MHC I molecule with the peptide binding region of human HLA-A*021 and presents the tyrosinase epitope. Tyr369. AAD + mice were bred with albino mice that lacked the expression of tyrosinase. A T cell clone specific for Tyr369 was isolat

• The numerically computed values of the

  2018-10-25

  

  The numerically computed values of the peak temperature and the analytically estimated values of the maximum shear stress, τmax, can be used further to provide an assessment of the longevity of the FSW tools with polygonal pin shapes. A tool durability index is therefore presumed here as the ratio o

• La corriente del psicoan lisis que se desarroll en

  2018-10-25

  

  La corriente del psicoanálisis que se desarrolló en Estados Unidos se apegó apoptosis inducer la teoría de las relaciones objetales, la cual dio prioridad al yo, haciéndolo el centro de la realidad del sujeto. Desde dicha perspectiva, se equipara al yo con una especie de conciencia, por lo que el tr

• Lo anterior se equipara con el

  2018-10-25

  

  Lo anterior se equipara con el periodo moderno tardío actual y con las dinámicas de la globalización que generan buena parte del ímpetu detrás del reciente frenesí de actividad legislativa relacionada con leyes internacionales de regulación de la prostitución. Aquí, los principales cambios y la crec

• En la interiorizaci n del

  2018-10-25

  

  En la interiorización del desprecio antes mencionada, también se interioriza un lenguaje y una forma de hablar de sí mismo, los cuales serán el ancla para las prácticas de sí. Por eso, para Monsiváis es tan importante que los sujetos puedan hablar sobre sí mismos. Solo en ese interregno entre la exp

• Introducci n Desde hace algunos a os la interseccionalidad s

  2018-10-25

  

  Introducción Desde hace algunos años, la interseccionalidad se ha convertido en la expresión utilizada para designar la perspectiva teórica y metodológica que busca dar cuenta de la percepción cruzada o imbricada de las relaciones de poder. Este enfoque no es novedoso dentro del feminismo y, de hec

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