Collectively we have evaluated the impact of

2018-10-20

Collectively, we have evaluated the impact of a MODY5-causing point mutation (S148L) in the HNF1B gene on human pancreas development using a unique human stem cell model. We report molecular phenotypes (up- and down-regulation of pancreatic genes) when HNF1B is increasingly expressed from days 7 to

The first consistency check we performed was that the normal

2018-10-20

The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

In this study we further show that expression

2018-10-20

In this study, we further show that Fostriecin sodium salt Supplier of SUV39H1 in HSC is controlled by the highly conserved miR-125 miRNA family. While previously shown to be important regulators of HSC self-renewal and differentiation potential (O\'Connell et al., 2010; Ooi et al., 2010), the contr

Despite the dramatic changes in

2018-10-20

Despite the dramatic changes in bone morphology in OsxCre;iDTR mutants, bone marrow cellularity was unaffected compared with their control littermates (Figure 3A). Red blood cell and platelet numbers were unchanged in the blood of the OsxCre;iDTR mutant, but there was a 50% decrease in the white blo

In BRGSKWv Wv mice the level of myeloid reconstitution

2018-10-20

In BRGSKWv/Wv mice, the level of myeloid reconstitution was up to 30% and 60% at 8–12 weeks and 20–24 weeks after transplantation, respectively. These levels might be comparable with those in MITRG mice in which four critical myeloid cytokines were humanized (Rongvaux et al., 2014), although a direc

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2018-07-29