• The additive impact of progressive changes

  2018-10-23

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

• br The products of the Fanconi anemia

  2018-10-23

  

  The products of the 19 Fanconi anemia (FA) genes play important and often biochemically collaborative roles in the repair of DNA interstrand crosslinks and regulation of cellular responses to the genotoxic stress imposed by cellular replication. In response to exogenous and endogenous (e.g. aldehy

• This movement may be facilitated by the

  2018-10-23

  

  This movement may be facilitated by the formation of hydrogen bonds in the CTT as shown in Fig. 5 and Supplementary Fig. S3a. In the cGAMP-bound form, the hydrogen bonds in L374 and R375 appeared to have anchored the end of the CTT to the Lid (Fig. 5b and Supplementary Fig. S3a). L374 is especially

• Bosch et al performed frequent sampling of the nasopharyngea

  2018-10-23

  

  Bosch et al. performed frequent sampling of the nasopharyngeal microbiome during the first 6months of life, a period not well-covered by previous studies (). Thus, this study captured for the first time the most dynamic changes that occur within the first two months of life, and also showed that the

• br Conflicts of Interest br Author Contributions br Acknowle

  2018-10-23

  

  Conflicts of Interest Author Contributions Acknowledgements Introduction Hepatitis C virus (HCV) is a major global public health problem. Although HCV incidence is declining, morbidity and mortality related to chronic HCV infection are increasing (Aspinall et al., 2015; Kuo et al., 2015)

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion We sought to define properties of anti-Env Abs critical for mucosal HIV-1 protection, addressing two major issues in the vaccine field: the need to prioritize induction of IgA rather than IgG, and broadly-neutralizing activities rather than other ant

• To reveal the molecular mechanism of MeCP

  2018-10-23

  

  To reveal the molecular mechanism of MeCP2 regulation, we performed a combination of microarray analysis and ChIP-Seq, through which we identified FOXF1 and MYOD1 as MeCP2 targeting genes. We confirmed that MeCP2 binds to the methylated CpG islands in the promoter regions of both genes, leading to d

• The outcome measures of efficacy of antibody replacement the

  2018-10-23

  

  The outcome measures of efficacy of antibody replacement therapy are summarized in Table 3 and Fig. 1. Anamnestically patients had a median number of 5.50 infections per year (interquartile range 4.00–8.00; available in 50 patients). In the year prior to ART the median number of antibiotic courses w

• br Conclusions and Future Questions In this

  2018-10-23

  

  Conclusions and Future Questions In this review, we have summarized current knowledge on biological age predictors and discussed different data types used. There are several existing predictors, where the most plausible candidates are the epigenetic clock and telomere length. They have both been

• The clear genetic link between breast cancer and

  2018-10-23

  

  The clear genetic link between breast cancer and the CCDC170 gene, and the earlier identification of another CCDC protein (MTCL1/CCDC165) that mediates the formation of a stable Golgi-derived microtubule network (Sato et al., 2014), provided a solid foundation for further exploration of the role of

• br Supplementary functional annotations of avian eggshell

  2018-10-23

  

  Supplementary functional annotations of avian eggshell matrix proteins Potential functions of proteins were determined according to the literature, data annotations and functional domain database and highlighted 77 proteins with potential functions related to a mineralization process [1]. Beside

• br The coefficient of resistance to

  2018-10-23

  

  The coefficient of resistance to humidity (Crh) is defined with respect to the resistance to crushing after five cycles of alternate watering and drying and the resistance to the simple alkylation of dna when dried. Crh: Coefficient of resistance to humidity, σmsa: The resistance to humid compre

• Gene ID Respective gene ID according to NCBI

  2018-10-23

  

  Gene ID: Respective gene ID according to NCBI. Gene name: rpkm.Control1-3: relative coverage of the control samples in three biological replicates. rpkm.Heat_stress1-3: relative coverage of the heat stress samples in three biological replicates. qv: statistical significance of the change. log2F

• The discount rates and factors reported in

  2018-10-23

  

  The discount rates and factors reported in this paper are derived based on an estimation of the Cox-Ingersoll-Ross (CIR) stochastic interest rate model [1]. The data can then be used to evaluate investment projects, even when their cash flows occur in the distant future. In the CIR model, the dynam

• br Materials and methods br

  2018-10-22

  

  Materials and methods Results and discussion The nanoparticles of RDX and HMX were precipitated immediately on the injection of their respective solution into antisolvent (water). Stirring was continued up to a few minutes after the injection to complete the mixing to precipitate smaller parti

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