In this study we further show that expression

2018-10-20

In this study, we further show that Fostriecin sodium salt Supplier of SUV39H1 in HSC is controlled by the highly conserved miR-125 miRNA family. While previously shown to be important regulators of HSC self-renewal and differentiation potential (O\'Connell et al., 2010; Ooi et al., 2010), the contr

Despite the dramatic changes in

2018-10-20

Despite the dramatic changes in bone morphology in OsxCre;iDTR mutants, bone marrow cellularity was unaffected compared with their control littermates (Figure 3A). Red blood cell and platelet numbers were unchanged in the blood of the OsxCre;iDTR mutant, but there was a 50% decrease in the white blo

In BRGSKWv Wv mice the level of myeloid reconstitution

2018-10-20

In BRGSKWv/Wv mice, the level of myeloid reconstitution was up to 30% and 60% at 8–12 weeks and 20–24 weeks after transplantation, respectively. These levels might be comparable with those in MITRG mice in which four critical myeloid cytokines were humanized (Rongvaux et al., 2014), although a direc

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2018-07-29