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br Author contributions br Conflicts
2023-03-11
Author contributions Conflicts of interest The authors declare no competing financial interests. Acknowledgement This work was supported by grants from the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich/Transregio 166–Project C1 and grant CA 1014/1-1 to D.C.) and the IZKF Würzbur
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cyp450 inducers Recent results suggest that TARPs are not th
2023-03-08
Recent results suggest that TARPs are not the only auxiliary AMPAR subunits. Using a proteomic strategy (affinity purification of native AMPAR complexes followed by mass-spectrometric analysis), cornichon-related proteins (CNIHs) have been recently identified as components of the AMPAR protein micro
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cyp450 inducers Recent results suggest that TARPs are not th
2023-03-08
Recent results suggest that TARPs are not the only auxiliary AMPAR subunits. Using a proteomic strategy (affinity purification of native AMPAR complexes followed by mass-spectrometric analysis), cornichon-related proteins (CNIHs) have been recently identified as components of the AMPAR protein micro
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17 aag br Author Contributions br Acknowledgments br Introdu
2023-03-08
Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to 17 aag tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeutic thro
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Due to metabolic variations it is important
2023-03-08
Due to metabolic variations, it is important to consider arginine metabolism and dependency in specific contexts to identify precise patterns. This is best illustrated for ASS: while ASS deficiency correlates with worse prognosis in sarcomas, ASS levels positively correlate with a poor prognosis in
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Diperodon HCl synthesis br Author contributions br Funding T
2023-03-08
Author contributions Funding This work was supported by the Czech Science Foundation, project no. 14-16220S. Additional support was provided by NIH R01CA117907 grant awarded to J.M.E. Conflict of interest Introduction The dioxin-like family includes polyhalogenated aromatic hydrocarbons
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69 8 receptor The results also showed that the A
2023-03-08
The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 69 8 receptor stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection model
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Introduction Pyometra is relatively common in intact
2023-03-08
Introduction Pyometra is relatively common in intact bitches and its diagnosis is aided by ultrasonography (Bigliardi et al., 2004), along with measurement of acute phase proteins and leucocyte (white blood cell, WBC) counts; assessment of these parameters during recovery may be helpful for monitor
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Materials and methods br Results br Discussion The BV tag
2023-03-08
Materials and methods Results Discussion The BV-tag-based electrochemiluminescence immunoassay is an extremely sensitive assay. It has been employed for detecting analytes present in only picogram quantities (e.g., bacterial toxins [26], PF 04418948 sale [19]), measuring the activity of basi
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Luciferase Immunoprecipitation Systems LIPS which utilizes r
2023-03-08
Luciferase Immunoprecipitation Systems (LIPS), which utilizes recombinant antigens fused to the enzyme reporter Renilla luciferase (Ruc) to detect patient antibodies, provides a unique platform to investigate phosphocholine mg directed against a variety of antigenic targets [25]. Previously, LIPS h
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The molecular mechanisms involved in the pathogenesis of cho
2023-03-07
The molecular mechanisms involved in the pathogenesis of cholestatic pruritus remain unknown [45], [46]. Indeed, there has been an enormous effort at understanding the etiology of PBC-related pruritus, including work at the cellular and molecular level, but such efforts have not been translated into
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Here we report discovery of highly selective pan
2023-03-07
Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of SB 216763 australia bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity of the interac
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α-Bungarotoxin It is now well established that
2023-03-06
It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar
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br Material and methods br
2023-03-06
Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st
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br Introduction Heart Failure HF is a major and growing
2023-03-06
Introduction Heart Failure (HF) is a major and growing health challenge in India and the developing countries. It is one of the most important causes of morbidity and mortality in the industrialized world. The incidence and prevalence estimates of HF are unreliable in India because of the lack of
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