• Always some extra effort may make great progress in

  2021-12-13

  

  Always, some extra effort may make great progress in sensing platform, for example, Ma's group discovered luminescent iridium (Ⅲ) complexes which were highly selective for G-quadruplex DNA and Al3+, then they utilized these complexes to develop a series of G-quadruplex-based probes and chemosensor r

• One of the main clinical issues of

  2021-12-13

  

  One of the main clinical issues of ABCB1, together with its impact on intestinal absorption, concerns its location at the BBB. Indeed, ABCB1 has been identified in the luminal side of endothelial cells and in the abluminal side of astrocyte endfeet processes of the CNS microvasculature [[36], [37],

• eif2a Discrepancies in the reported results

  2021-12-13

  

  Discrepancies in the reported results and conclusions from different groups regarding studies in ghrelin−/− and ghsr−/− mice are likely explained by the mixed background of the mutant mice used in the different studies [35]; although in the case of mice exposed to HFD, exposure to a HFD immediately

• Glucocorticoid is a major regulator of body s

  2021-12-13

  

  Glucocorticoid is a major regulator of body's response to stress (Armario, 2006). Repeated injections of the glucocorticoid corticosterone (CORT) in mice have been shown to produce an animal model of depression (Zhao et al., 2008). Further study of this phenomenon suggested that prolonged CORT expos

• br Materials and methods br Results and discussion br

  2021-12-13

  

  Materials and methods Results and discussion Conclusions Acknowledgments The authors are grateful to Dr. N. Prevete for providing the human AGS shCTR and AGS shFPR2 cells. This work was supported by POR Campania FSE 2007-2013 Project CREME and Ministry of Health, Italy, RF-2011-02349269

• br Molecular aberrations in the FGFR

  2021-12-13

  

  Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated NADP/NADPH Quantitation Colorimetric Kit analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xen

• In our cohort each patient had a median of

  2021-12-13

  

  In our cohort, each patient had a median of 2 Anti-FXa measurements performed daily and a median of 1 infusion rate change daily to maintain therapeutic unfractionated heparin levels. Previously, several studies have documented that APTT-based protocols lead to more fluctuations in comparison with A

• In summary we have provided evidence that TA a novel

  2021-12-13

  

  In summary, we have provided evidence that TA, a novel HATi, inhibits the acetylation of histone and non-histone proteins and activation of the mRNA expression of lipogenesis-related genes both in vitro and in vivo (Figure 8), indicating that inhibition of HAT activity by TA is necessary for the pre

• HOs can be found in

  2021-12-10

  

  HOs can be found in both plants and animals and they are evolutionarily conserved proteins [8]. There are two HO isoenzymes: inducible heme oxygenase-1 (HO-1) and constitutive heme oxygenase-2 (HO-2) encoded by different genes [9,10]. Biosynthesis of a stress-inducible HO-1 can be triggered by a var

• br Trifluoromethylketones This group of compounds was demons

  2021-12-10

  

  Trifluoromethylketones This group of compounds was demonstrated to bind the zinc Raloxifene HCl in the active site due to its easy hydration, forming the required chelating intermediate. Ontaria et al. [92] have proposed variations around the cap group of trifluoromethylthiophene as the core moti

• It is essential to maintain genome integrity and stability w

  2021-12-10

  

  It is essential to maintain genome integrity and stability which is assaulted by oxidative stress. To perform this function, all human cells have well developed repair systems. Base excision repair (BER) system is the most effective pathway responsible to revert back lesions caused by oxidative stre

• br Concluding remarks br Introduction The hair cells

  2021-12-10

  

  Concluding remarks Introduction The hair MCC950 sodium of vestibular organs detect linear and rotational head movements, providing sensory information that is essential for normal postural and visual reflexes. Most vestibular hair cells are produced during embryonic development, but they can

• Although NCT undergoes complex glycosylation processing for

  2021-12-10

  

  Although NCT undergoes complex glycosylation processing for maturation through trafficking from endoplasmic reticulum to Golgi or additional compartments, the effect of NCT glycosylation on γ-secretase activity and substrate specificity is still unknown. The present study focused on glycosylation st

• The GH family has potential applications in various industri

  2021-12-10

  

  The GH family has potential applications in various industries. A putative ORF encoding α-galactosidase, namely GalR, with a low identical match and e-value and high query coverage in the metagenome was selected because it demonstrated considerable activity. GalR shared 65% identity with the GH 27 p

• br Methods br Results It is well known

  2021-12-10

  

  Methods Results It is well known that during the onset of vasoconstriction there is an increase in intracellular Ca2+ which activates myosin light-chain kinase followed by cycling of actin-myosin cross-bridges in VSMCs. Recently, it has been recognized that aim products polymerization is also

15718 records 508/1048 page Previous Next First page 上5页 506507508509510 下5页 Last page