• br Materials and methods br Results and

  2020-08-10

  

  Materials and methods Results and discussion Conclusions In this study, we have investigated the possibility that hierarchical phosphorylation by CK2 may play a role in cellular signal transduction. Hierarchical phosphorylation by CK2 requires multiple consensus determinants with specific s

• br Significance Ubl post translational modifications are pot

  2020-08-10

  

  Significance Ubl post-translational modifications are potential targets for developing novel therapeutics for life-threatening diseases, such as c-Myc- and KRas-driven cancers that lack targeted therapy. However, only a few drugs are available to target these modifications. This lack of drugs hig

• Collectively the results presented here

  2020-08-10

  

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of

• The significance of the difference in the DDR binding specif

  2020-08-10

  

  The significance of the difference in the DDR2 binding specificity towards fibrillar and non-fibrillar collagens is not understood, but may imply differences in biological responses when chondrocytes bind to different collagens in the growth plate. Investigations by Labrador et al. (2001) have shown

• br EBV Infection Epstein Barr virus EBV human herpesvirus

  2020-08-10

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• CK comprises a family of serine threonine protein kinases th

  2020-08-08

  

  CK1 comprises a family of serine/threonine protein kinases, that includes different CK1 isoforms namely α, β, δ, ε and γ their various splice variants [56]. It was reported that the pharmacological inhibitor IC261 shows an order of magnitude of higher selectivity for CK1δ or CK1ε isoforms (IC50 of 1

• 4-ethylphenyl sulfate It has previously been shown that huma

  2020-08-08

  

  It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of 4-ethylphenyl sulfate on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] report

• Researches aforementioned provide effective numerical theore

  2020-08-08

  

  Researches aforementioned provide effective numerical/theoretical descriptions of expansion behavior of PELE when small-caliber projectiles penetrating thin target at high impact velocity. Here we presented a similar study on large-caliber PELE projectile (130 mm) with various thickness steel jacket

• Imaging of primary Tfh cells at the peak of

  2020-08-08

  

  Imaging of primary Tfh cells at the peak of the GC response revealed clear spatial segregation in the FM and GC compartments. This confinement was confirmed by TPP and discontinuous cell tracking 24 hr later, which showed retention of the majority of photoconverted GC Tfh cells in the original GC an

• Chemokine receptor expression in MZL subtypes

  2020-08-07

  

  Chemokine receptor expression in MZL subtypes is shown in Table 1. CXCR3 is strongly expressed on the surface of the majority of MZLs and was identified via IHC in 14/14 (100%) patients with splenic MZL, 15/16 (94%) patients with extranodal MZL [4] and 5/5 (100%) cases of epidermotropic MZL [176]. O

• br RINGs as activators of E Ub In

  2020-08-07

  

  RINGs as activators of E2~Ub In Diclofenac to HECT-type E3 ligases, RING-type E3s lack a bona fide catalytic center. A lingering question in the field has been whether RINGs serve solely to position E2~Ub relative to the substrate, or if they also serve as activators of E2~Ub. Clearly, unwanted

• From a structural point of view the

  2020-08-06

  

  From a structural point of view, the McOYEs share the TIM barrel scaffold typical of the OYEs family where structural variability is associated with the capping subdomain that is a flexible region involved in active site shaping and also in NAD(P)H and substrate binding. Interestingly, the crystal s

• One possible explanation for differences in the

  2020-08-06

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• br Author contributions br Disclosure statement br Transpare

  2020-08-06

  

  Author contributions Disclosure statement Transparency document Acknowledgements This work is part of a research program, which is financed by the Province of Fryslân (01120657), the Netherlands and Alfasigma Nederland B.V (direct contribution to grant number 01120657). Introduction

• The TMS is considered failed if either the monitoring

  2020-08-06

  

  The TMS is considered failed if either the monitoring application provides to the operator wrong information that do not reflect the real railways status (functional failure), or if the service completely stops being provided (non-functional failure). The architecture currently adopted by ASTS, ther

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