• One major drawback of current melanoma

  2018-11-09

  

  One major drawback of current melanoma therapy is the development of resistance mechanisms against novel therapeutics targeting the MAPK members RAF or MEK. Upon MAPK inhibition, additionally acquired mutations reactivate the MAPK pathway by gain of RAF gene copy numbers (Shi et al., 2012; Villanuev

• MBD was originally identified as a

  2018-11-09

  

  MBD3 was originally identified as a member of the methyl-CpG binding domain (MBD) family of proteins (Hendrich and Bird, 1998). However, unlike MBD members MECP2 and MBD1, 2, and 4, MBD3 does not bind methylated DNA (Hendrich and Bird, 1998; Zhang et al., 1999). Three MBD3 isoforms (MBD3A, B, and C)

• A lag by even a few milliseconds during

  2018-11-09

  

  A lag by even a few milliseconds during neuronal activation can sometimes completely transform the response signal affecting the rest of the nervous system, Optogenetics fundamentally enhances the temporal precision of traditional manipulations used for studying the roles of specific genes in cells,

• where L is the integration

  2018-11-09

  

  where L is the anti fungal path, we obtain the displacement field in each area of the composite. This procedure leads to the following expressions for the stresses in areas : where (p, α1, α2, β, μ, θ) are non-singular functions, while The elastic properties of the structure are expressed in t

• br Methods br Results In the entire study

  2018-11-09

  

  Methods Results In the entire study population, 8.0% of the schoolchildren were physically inactive (Table 1). The prevalence of physical inactivity varied by year with a peak in 1998 and 2002 but was generally characterized by an overall decreasing tendency (test for trend, phydroxycarboxylic

• br Conflict of interest br

  2018-11-09

  

  Conflict of interest Acknowledgement Support for manuscript preparation was provided by grants from the National Institutes of Health (MH094633, MH103627) to Koraly Pérez-Edgar. Introduction Materials and methods Results Discussion We investigated the impact of music training on t

• br Role of the authors

  2018-11-09

  

  Role of the authors Alex Padovano: Performed literature search in 13 languages, selected papers for further review, entered eligible case reports in Excel spreadsheet, performed basic statistical analyses, created Fig. 1. Ying Zhou: Chose and performed statistical tests and created Table 1 and F

• Expression levels of the parasympathetic receptor nAChR on p

  2018-11-09

  

  Expression levels of the parasympathetic receptor α7nAChR on peripheral blood monocytes could be evaluated in a subset of AR subjects. Expression levels were significantly decreased in individuals with RHR ≥70bpm compared to those with RHR immune bethanechol chloride (Koopman et al., 2011); it is c

• Clinical implementations with interventional protocols are s

  2018-11-09

  

  Clinical implementations with interventional protocols are starting using this assay permitting distinction between patients without any over-risk of toxicity (considered as resistant to late effects) and patients clearly at risk of developing more late effects defined as very sensitive (). In terms

• br Methods The donor pig herd

  2018-11-09

  

  Methods The donor pig herd (Auckland Island pigs; Living Cell Technologies, Manukau, New Zealand, and Diatranz Otsuka Ltd, Auckland New Zealand) was maintained in a designated pathogen-free facility and screened for an extensive panel of infectious agents including porcine endogenous retrovirus (

• br Developmental changes in metaplasticity align with hippoc

  2018-11-09

  

  Developmental changes in metaplasticity align with hippocampal maturation The hippocampus is required for contextual learning in rats and mice. This statement is derived predominantly from hippocampal lesion studies involving contextual learning and memory tasks such as spatial navigation to a go

• br Conflict of interest br

  2018-11-09

  

  Conflict of interest Acknowledgements This work was supported by a grant from the Belgian National Fund for Scientific Research (FNRS 3.4.516.08.F). Stéphane A. De Brito was supported by a research fellowship from the Swiss National Science Foundation (SNSF PA00P1_139586). Introduction Att

• La profunda reacci n conservadora que hemos experimentado

  2018-11-09

  

  La profunda reacción conservadora que hemos experimentado en el plano de las ideas, de la que la degradación del debate sobre el desarrollo económico no es más que una expresión, no se explica, por tanto, por la supuesta fortaleza teórica de las ideas neoliberales hoy imperantes en el seno de la “ci

• The response variable of the

  2018-11-09

  

  The response variable of the models is binary, defined by the occurrence of at least one type of crime analyzed over the Aprotinin covered by the victimization surveys (victim). It assumes value 1 if the individual i was victimized and 0 otherwise. Given this characteristic of the dependent variabl

• Mature miRs act by destabilising mRNAs with some degree

  2018-11-09

  

  Mature miRs act by destabilising mRNAs with some degree of complementarity or by repressing protein translation, leading to down regulation of target genes and changes in biological functions (Bohnsack et al., 2004; Chen and Rajewsky, 2007; Kim, 2005; Lee et al., 2003). The expression of miRs is tig

15019 records 982/1002 page Previous Next First page 上5页 981982983984985 下5页 Last page