• br Materials and methods br Results and discussion br Conclu

  2018-10-24

  

  Materials and methods Results and discussion Conclusions The centre composite design of response surface methodology was successfully used in optimising the reaction conditions for biodiesel production from waste vegetable oil in the presence of Biotin-tyramide heterogeneous catalyst prepar

• has been a remarkable year of scientific achievements from a

  2018-10-23

  

  2014 has been a remarkable year of scientific achievements, from advances in our understanding of molecular pathways of human diseases to the development of new interventional tools to tackle them. Here, we highlight some promising initiatives and success stories from the past year with clear transl

• The original premise of this

  2018-10-23

  

  The original premise of this study was that the melanoma-enriched miRNAs identified in our previous study (Stark et al., 2015) would be translated directly to the expression observed in melanoma patient-derived serum. Evidence for this notion is apparent in the serially collected stage IV melanoma p

• Vaccine studies conducted in both non human primate models A

  2018-10-23

  

  Vaccine studies conducted in both non-human primate models (Alpert et al., 2012; Gómez-Román et al., 2005; DeVico et al., 2007; Hidajat et al., 2009; Xiao et al., 2010; Brocca-Cofano et al., 2011; Barouch et al., 2012) and humans (Forthal et al., 2007; Haynes et al., 2012) have also suggested that A

• br Acknowledgments Funding for this

  2018-10-23

  

  Acknowledgments Funding for this study was obtained from the South African Medical Research Council for self-initiated research from November 2012 to April 2015 and the Lily and Ernst Hausmann Research Trust to Bongani Mayosi, and the National Institute of Allergy and Infectious Diseases of the N

• Second the uncertainty in the vector and human parameters af

  2018-10-23

  

  Second, the uncertainty in the vector and human parameters affect the value of DEP through VC and the threshold value for intensity. All six vector parameters depend on temperature. The female vector-to-human population ratio depends on temperature the same way as longevity (Brady et al., 2014). The

• The additive impact of progressive changes

  2018-10-23

  

  The additive impact of progressive changes in sleep quality and structure, changes in cerebral blood flow, neurovascular and neurotransmitters, plus the cellular redox status are all likely to contribute to the cognitive deficits reported in up to one out of four newly diagnosed OSA patients (Rosenz

• br The products of the Fanconi anemia

  2018-10-23

  

  The products of the 19 Fanconi anemia (FA) genes play important and often biochemically collaborative roles in the repair of DNA interstrand crosslinks and regulation of cellular responses to the genotoxic stress imposed by cellular replication. In response to exogenous and endogenous (e.g. aldehy

• This movement may be facilitated by the

  2018-10-23

  

  This movement may be facilitated by the formation of hydrogen bonds in the CTT as shown in Fig. 5 and Supplementary Fig. S3a. In the cGAMP-bound form, the hydrogen bonds in L374 and R375 appeared to have anchored the end of the CTT to the Lid (Fig. 5b and Supplementary Fig. S3a). L374 is especially

• Bosch et al performed frequent sampling of the nasopharyngea

  2018-10-23

  

  Bosch et al. performed frequent sampling of the nasopharyngeal microbiome during the first 6months of life, a period not well-covered by previous studies (). Thus, this study captured for the first time the most dynamic changes that occur within the first two months of life, and also showed that the

• br Conflicts of Interest br Author Contributions br Acknowle

  2018-10-23

  

  Conflicts of Interest Author Contributions Acknowledgements Introduction Hepatitis C virus (HCV) is a major global public health problem. Although HCV incidence is declining, morbidity and mortality related to chronic HCV infection are increasing (Aspinall et al., 2015; Kuo et al., 2015)

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion We sought to define properties of anti-Env Abs critical for mucosal HIV-1 protection, addressing two major issues in the vaccine field: the need to prioritize induction of IgA rather than IgG, and broadly-neutralizing activities rather than other ant

• To reveal the molecular mechanism of MeCP

  2018-10-23

  

  To reveal the molecular mechanism of MeCP2 regulation, we performed a combination of microarray analysis and ChIP-Seq, through which we identified FOXF1 and MYOD1 as MeCP2 targeting genes. We confirmed that MeCP2 binds to the methylated CpG islands in the promoter regions of both genes, leading to d

• The outcome measures of efficacy of antibody replacement the

  2018-10-23

  

  The outcome measures of efficacy of antibody replacement therapy are summarized in Table 3 and Fig. 1. Anamnestically patients had a median number of 5.50 infections per year (interquartile range 4.00–8.00; available in 50 patients). In the year prior to ART the median number of antibiotic courses w

• br Conclusions and Future Questions In this

  2018-10-23

  

  Conclusions and Future Questions In this review, we have summarized current knowledge on biological age predictors and discussed different data types used. There are several existing predictors, where the most plausible candidates are the epigenetic clock and telomere length. They have both been

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